Bone Marrow Transplant
BLK Centre for Bone Marrow Transplant (BLKBMT) is the largest in India and amongst the biggest in Asia. BLKBMT is a stand alone dedicated facility, equipped with ultra-modern infrastructure and internationally trained, widely experienced faculty. The Centre is supported by state-of-the-art laboratory services and transfusion services, along with a fully equipped radiation oncology unit with facility for total body irradiation. The Centre offers both allogenic and autologous transplant using bone marrow, peripheral blood stem cells and cord blood stem cells for various benign and malignant disorders like Thalassemia, Aplastic Anaemia, Leukemia, Lymphomas, Multiple Myelomas and Advanced Paediatric Solid Tumors. BLKBMT has to its credit more than 650 transplants within a short span.
Key Department Highlights- BLK Centre for Bone Marrow Transplant is one of the largest centres of its kind across Asia
- The centre has performed the maximum number of transplants in north India
- Each room is supported by separate HEPA filter with triple level air filtration
- Transplants are routinely performed for children as well as adults
Bone marrow transplantation is a procedure wherein stem cells from bone marrow that produce various blood cells like red blood cells, white blood cells and platelets are injected into a recipient. These stem cells are also referred to as hematopoietic stem cells. Nowadays, hematopoietic stem cells may also be obtained from peripheral blood after treatment with certain growth factors or from umbilical cord. Thus, the term �Hematopoietic stem cell transplantation� is now preferred to �Bone marrow transplantation� to include these other sources of hematopoietic stem cells.
The bone marrow is a soft, spongy portion within a bone. It contains immature cells called stem cells that have a continuous ability to produce different types of blood cells i.e. red blood cells, white blood cells and platelets. These are released into the blood stream. Bone marrow is of two types, red marrow and yellow marrow. In children, most of the marrow is red marrow and is rich in stem cells. In adults, however, a large portion of the bone marrow is converted into yellow marrow due to infiltration of fat cells. Red marrow in adults is usually restricted to a few bones like the hip bones, breast bone, ribs, shoulder blades, skull, backbone, and the ends of the arm and thigh bones.
BMT is actually means infusion of stem cells (collected either from bone marrow or peripheral blood or cord blood) into the recipient. The type of bone marrow that is used for the transplant distinguishes the different types of BMT.
- Autologous BMT is done by using the patient's own stem cells.
- Allogeneic BMT involves using the stem cells of a donor. The donor may be a relative, usually a brother or sister, or an unrelated (anonymous) donor. The donor needs to be Histocompatible Leukocyte antigen (HLA) match.
Team of Doctors
Dr. Dharma Choudhary
- Dr. S. N. Medical College, Jodhpur, Rajasthan
- Christian Medical College, Vellore
- Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow
- All India Institute of medical Sciences, New Delhi
- Leukemia/BMT program of British Columbia, Vancouver General Hospital and BC Cancer Agency, Canada.
- Sir Ganga Ram Hospital, New Delhi
Allogenic Bone Marrow Transplant, Hemato-Oncology Graft Versus Host Disease
MembershipIndian Society of Hematology & Transfusion Medicine (Life Member)
Research and Publications- Sharma SK, Handoo A, Choudhary D, Dhamija G, Gupta N. Severe gastrointestinal mucositis following high dose Melphalan therapy for multiple myeloma. World J Gastroenterol. 2013 Feb 7; 19(5):784-5.
- Sharma SK, Choudhary D, Handoo A, Kharya G, Gupta N, Pavecha P, Chadha R. Gelatinous transformation of bone marrow following the use of dasatinib in a patient with philadelphia chromosome positive acute lymphoblastic leukemia. Leuk Res Reports 2013; 2: 7�8.
- Choudhary D, Sharma SK, Gupta N, Kharya G, Pavecha P, Handoo A, Setia R, Katewa S. Treosulfan-thiotepa-fludarabine-based conditioning regimen for allogenic transplantation in patient with thalassemia major : a single center experience from north India. Biol Blood Marrow Transplant. 2013 Mar; 19(3):492-5.
- Monica Jain, Anil Handoo, Dharma R Choudhary, Atul Bhasin. Flow Cytometry: A Rapid and Robust Adjuvant Technique for Pathological Diagnosis. Turk J Hematol 2012; 29: 82-84.
- Rangan A, Choudhary DR, Sinha S, Handoo A, Bhargava M. Secondary Myelofibrosis in a case of Aplastic Anaemia, a case report. Journal of Clinical and Diagnostic Research [serial online] 2009 June [cited: 2009 June 1]; 3:1587-1590.
- Choudhary DR, Naithani R, Panigrahi I, Kumar R, Mahapatra M, Pati HP, Saxena R, Choudhry VP . Effect of wheat grass therapy on transfusion requirement in thalassaemia major. Indian J Pediatr.2009 Feb 10. {Epub ahead of print}
- Choudhary DR, Naithani R, Mahapatra M, Kumar R, Mishra P, Saxena R. Intracranial hemorrhage in childhood immune thrombocytopenic purpura. Pediatr Blood Cancer. 2008 Dec 4. [Epub ahead of print]
- Choudhary DR, Naithani R, Mahapatra M, Kumar R, Mishra P, Saxena R. Efficacy of Cyclosporine as a single agent therapy in chronic idiopathic thrombocytopenic purpura. Haematologica 2008 93: e61-e62
- Dixit A, Chatterjee T, Mishra P, Kannan M, Choudhary DR, Mahapatra M, Choudhry VP, Saxena R. Disseminated intravascular coagulation in acute leukemia at presentation and during induction therapy.
- Clin Appl Thromb Hemost. 2007 Jul; 13(3):292-8.
- Choudhary DR, Bhattacharya M, Mishra P, Mahapatra M, Kumar R. Granulocytic sarcoma of spine: an unusual initial presentation of acute myeloid leukemia. J Assoc Physicians India. 2006 Nov; 54:897.
- Mishra P, Kumar R, Mahapatra M, Sharma S, Dixit A, Chaterjee T, Choudhry DR, Saxena R, Choudhry VP. Tuberculosis in acute leukemia: a clinico-hematological profile. Hematology 2006 Oct; 11(5): 335-40.
- Panigrahi I, Agarwal S, Pradhan M, Choudhary DR, Choudhry VP, Saxena R. Molecular characterization of thalassaemia intermedia in Indians. Haematologica. 2006 Sep; 91(9): 1279-80.
- Kumar R, Prem S, Mahapatra M, Seth T, Chowdhary DR, Mishra P, Pillai L, Narendra AM, Mehra NK, Saxena R and Choudhry VP. Fludarabine, Cyclophosphamide and horse antithymocyte globulin conditioning regimen for allogeneic peripheral blood stem cell transplantation performed in non-HEPA filter rooms for multiply transfused patients with severe aplastic anemia.
- Bone Marrow Transplant. 2006 Mar 6
- Choudhary Dharma R, Mishra P, Kumar R, Mahapatra M, Choudhry VP. Pregnancy while on Imatinib: Meningocele and fetal outcome. Ann Oncol. 2005 Nov 15;
- Chatterjee T, Dixit A, Mishra P, Naithani R, Srinivas MU, Mahapatra M, Tyagi S, Pati HP, Dutta P, Bhattacharya J, Choudhary DR, Kumar R, Choudhry VP, Saxena R. Primary Myelodysplastic syndrome in children- clinical, hematological and histomorphologic profile from a tertiary care center from India . Hematology. 2005 Dec; 10(6):495-9.
- P Mishra, Pati HP, Chatterjee T, Dixit A, Choudhary DR, Srinivas MU, Mahapatra M, Choudhry VP. Hb SE disease: a clinico-hematological profile. Ann Hematol. 2005 Oct; 84(10):667-70.
- Dixit A, Chatterjee TC, P Mishra, Choudhary DR, Mahapatra M, Tyagi S, Kabra M, Saxena R, Choudhry VP. Hydroxyurea in thalassaemia intermedia -a promising therapy. Ann Hematol. 2005 Jul; 84(7): 441-6
- P Mishra, Mahapatra M, Kumar R, Dixit A Chatterjee T, Tyagi S, Choudhary DR, Sazawal S, Choudhry VP. Philadelphia-chromosome positive thrombocythemia in a child. Eur J Haematol. 2005 Sep; 75(3): 262-3.
- Dixit A, Chatterjee TC, P Mishra, Choudhary DR, Mahapatra M, Saxena R, Choudhry VP. Cyclosporine A in Myelodysplastic syndrome: a preliminary report. Ann Hematol. 2005 Sep; 84(9): 565-8.
- Chapters in Book
- Rajat Kumar, Dharma R Choudhary, Manoranjan Mahapatra, Renu Saxena. Idiopathic Thrombocytopenic Purpura, An Indian Perspective. In Clinical Medicine, 2007 ; 324-333. Published by Jaypee Brothers.
- Dharma R Choudhary, VP Choudhry. Future in thalassemia. In Hemoglobinopathies, 2005; 249-255. Published by Jaypee Brothers.
- VP Choudhry, DR Choudhary. Pathophysiology of Sickle cell disease. In Hemoglobinopathies, 2005; 277-2286. Published by Jaypee Brothers
Dr. Sanjeev Kumar Sharma
- Senior Resident in the Department of Hematology, AIIMS, New Delhi
- Senior Resident in the Department of Internal Medicine and Hematology at PGIMER, Chandigarh, India
- Junior Residency in Regional Blood Transfusion Centre, GTB Hospital, Delhi
- Junior Residency in Department of Burns and Plastic Surgery, Guru Teg Bahadur Hospital, Delhi
- Cardiological Society of India / Interventional Council Annual Conference
- Singapore Live (Asia Pacific PCR)
- India Live 2010/2011
- CAD (Asia Interventional Meeting) Conference Pune
- ISIIC Warsaw
- Best Citizen of India Award 2014
- Gold Medal for Best MD Thesis Presentation
- 2nd Prize for Paper presentation in Diabetes and CAD
- Registered member Indian Society of Hematology and Blood Transfusion (ISHTM)
- Registered member of Delhi Medical Association (DMA)
- Member of Indian Society for Atherosclerosis Research (ISAR)
- Sharma SK, Handoo A, Choudhary D, Gupta N. Unusual cytogenetic abnormalities associated with Philadelphia chromosome. World J Hematol 2014
- Sharma SK, Kumar S, Vijayakumar AR, Seth T, Mishra P, Mahapatra M, et al. Utility of the trough plasma imatinib level monitoring at two time points in patients with the chronic myeloid leukemia- chronic phase. J Can Res Ther 2014;10:305-8
- Sharma SK, Choudhary D, Gupta N, Dhamija M, et al. Cost of Hematopoietic Stem Cell Transplantation in India. Mediterr J Hematol Infect Dis 2014, 6(1): e2014046, DOI: 10.4084 / MJHID.2014.046
- Sharma SK, Kumar S, Agarwal N, Singh L, Mukherjee A, Seth T et al. Cytomegalovirus reactivation following hematopoietic stem cell transplantation. J Infect Dev Ctries 2013; 7(12):1003-1007. doi:10.3855/jidc.2947
- Sharma SK, Kumar S, Singh AK, Seth T, Mishra P, Mahapatra M, Sharma S, Tyagi S, Xess I, Ray R. Feasibility and outcome of CT-guided lung biopsy in patients with hematological diseases and suspected fungal pneumonia. J Infect Dev Ctries. 2013;7(10):748-752. doi: 10.3855/jidc.2823. PubMed PMID: 24129628.
- Sharma SK, Agrawal N, Seth T, Kumar S, Mishra P, Mahapatra M. Oral High Dose Dexamethasone for Pure Red Cell Aplasia Following ABO-Mismatched Allogeneic Peripheral Blood Stem Cell Transplantation: A Case Report. Indian J Hematol Blood Transfus, 2013. DOI 10.1007/s12288-013-0276-x
- Sharma SK, Handoo A, Choudhary D, Dhamija G, Gupta N. Severe gastrointestinal mucositis following high dose melphalan therapy for multiple myeloma. World J Gastroenterol. 2013; 19(5): doi:10.3748/wjg.v19.i5.1
- Sharma SK, Choudhary D, Handoo A, Kharya G, Gupta N, Pavecha P, Chadha R. Gelatinous transformation of bone marrow following the use of dasatinib in a patient with philadelphia chromosome positive acute lymphoblastic leukemia. Leuk Res Reports 2013; 2: 7�8.
- Sharma SK, Gupta S, Durgapal P, Seth T, Mishra P, Mahapatra M, et al. Disseminated Histoplasmosis in a Patient with Aplastic Anemia. Indian J Hematol Blood Transfus, 2012. doi 10.1007/s12288-012-0198-z
- Sharma SK, Kumar S, Seth T, Mishra P, Agrawal N, Singh G, Singh AK, Mahapatra M, et al. Clinical Profile of Patients with Rare Inherited Coagulation Disorders: A Retrospective Analysis of 67 Patients from Northern India. Mediterr J Hematol Infect Dis 2012, 4(1): e2012057, doi 10.4084/MJHID.2012.057
- Sharma SK, Singh AK, Singh PK, Mishra P, Vanathi M, Das M, et al. Aplastic Anemia in a Patient With Wilson�s Disease. J Hematol 2012. doi: http://dx.doi.org/10.4021/jh39e
- Sharma SK, Kumar S, Singh AK, Seth T, Mishra P, Sharma S, Mahapatra M. Diffuse Alveolar Hemorrhage Following Allogeneic Peripheral Blood Stem Cell Transplantation: A Case Report and A Short Review. Indian J Hematol Blood Transfus, 2012. doi 10.1007/s12288-012-0184-5.
- Sharma SK, Singh PK, Seth T, Mishra P, Mahapatra M. Antithymocyte Globulin Induced Recurrent Seizures in a Case of Severe Aplastic Anemia. Indian J Hematol Blood Transfus, 2012. doi 10.1007/s12288-012-0183-6.
- Sharma SK, Sharma M, Seth T, Mishra P, Chowdhry M, Mahapatra M, et al. Clinical profile and outcome of patients of acute myeloid leukemia with high hyperdiploidy. Leuk. Res. 2012;36(3):60-61.
- Sharma SK, Mishra P, Seth T, Mahapatra M. Ileal ulceration during all-trans-retinoic acid therapy for acute promyelocytic leukemia. Leuk. Res. 2011;35(6):89-90.
- Sharma SK, Seth T, Mishra P, Mahapatra M. Bone Infarcts in a Case of Chronic Myeloid Leukemia: Chronic Phase. Indian Journal of Hematology and Blood Transfusion. 2011;1�2.
- Sharma SK, Seth T, Mishra P, Gupta N, Agrawal N, Broor S, et al. Clinical Profile of Dengue Infection in Patients with Hematological Diseases. Mediterranean Journal of Hematology and Infectious Diseases. 2011;3(1):2011039.
- Sharma SK, Agrawal N, Mukherjee A, Seth T, Mishra P, Xess I, et al. Coexisting Pulmonary Tuberculosis and Mucormycosis in a Patient with Aplastic Anemia Post Allogenic Stem Cell Transplantion. Mediterranean Journal of Hematology and Infectious Diseases. 2011;3(1):2011036.
- Sharma SK, Seth T, Agrawal N, Mahapatra M, Mishra P. Immune thrombocytopenic purpura following anti-rabies vaccines. Platelets. 2011:1�2.
- Sharma SK, Gupta S, Seth T, Mishra P, Mahapatra M, Singh MK, et al. Leukemia Cutis: An Unusual Presentation. Indian Journal of Hematology and Blood Transfusion. 2011;1�3.
- Sharma SK, Gupta N, Seth T, Srinivas M, Mishra P, Mahapatra M. Successful Management of Refractory Chronic Immune Thrombocytopenia with Intracranial Hemorrhage by Emergency Splenectomy. Indian J Pediatr. 2011 ;Available from: http://www.ncbi.nlm.nih.gov/pubmed/21761122
- Sharma SK, Gupta N, Arava S, Seth T, Mishra P, Mahapatra M, Mathur S, Sharma S. Pulseless Right Upper Limb: An Unusual Manifestation of Invasive Pulmonary Aspergillosis in Acute Myeloid Leukemia. J Assoc Physicians India, 2012;60:119-21.
- Sharma SK, Kumar S, Seth T, Mishra P, Mahapatra M. Eosinophilia: Rare cause of arterial thrombosis and cardioembolic stroke in childhood. World J Cardiol 2012;26: 4.
- Sharma SK, Agrawal N, Jain S, Chowdhry M, Singh PK, Seth T, Mishra P, Mahapatra M, Tyagi S, Pati H. An unusual clonal cytogenetic abnormality with t(15;17)(p11;q21) in a patient with severe aplastic anemia. Indian J Hum Gen. 2012;18:268-69.
- Sharma SK, Mukherjee A, Singh AK, Seth T et al. Madurella Mycetomatis Infection Following Allogenic Stem Cell Transplantation for Aplastic Anemia. Mediterr J Hematol Infect Dis. 2012; 4(1): e2012038. doi: 10.4084/MJHID.2012.038.
- Choudhary D, Sharma SK, Gupta N, Kharya G, Pavecha P, Handoo A, Setia R, Katewa S. Treosulfan-Thiotepa-Fludarabine- based conditioning regimen for allogeneic transplantation in patients with thalassemia major: a single-center experience from north India. Biol Blood Marrow Transplant. 2012 Nov 15. doi:pii: S1083-8791(12)00480-6. 10.1016/j.bbmt.2012.11.007.
- Choudhary D, Sharma SK, Gupta N, Handoo A. Stem cell transplant for juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Indian J Hematol Blood Transfus. 2013 doi 10.1007/s12288-013-0233-8.
- Kapoor J, Agrawal N, Ahmed R, Sharma SK. Factors Influencing Adherence to Imatinib in Indian Chronic Myeloid Leukemia Patients: A Cross-Sectional Study. Mediterr J Hematol Infect Dis. 2015;7.
- Kharya G, Sharma SK, Sharma R, Khilnani P. Pediatric Hematopoietic Stem Cell Transplantation. Journal of Pediatric Critical Care. 2015:1;14-23.
- Gupta N, Choudhary D, Sharma SK, Khandelwal V, Dhamija M. Haploidentical hematopoietic SCT for acquired severe aplastic anemia using post-transplant high-dose CY. Bone Marrow Transplantation. 2014, 1�2.
- Gupta N, Sharma SK, Seth T, Mishra P, Mahapatra M, Kumar S, et al. Rituximab in Steroid Refractory Autoimmune Hemolytic Anemia. Indian J Pediatr. 2011 8; Available from: http://www.springerlink.com content/ c4v573874111j305.
- Gupta N, Gupta SK, Rathi S, Sharma SK, Mahapatra M, Seth T, et al. Acute lymphoblastic leukemia presenting as non-oliguric renal failure and hypertension. Leukemia research. 2010;34(7):150.
- Singh AK, Dixit G, Sharma SK, Kumar S, Yadav R, Agarwal N, Mishra P, Seth T et al. Skin Manifestations Associated With Mantle Cell Lymphoma: a Case Report Mediterranean Journal of Hematology and Infectious Diseases 2013, 5(1): e2013020, DOI: 10.4084/MJHID.2013.020
- Sood P, Seth T, Kapil A, Sharma V, Dayama A, Sharma SK, Kumar S, Singh AK, Mishra P, Mahapatra M. Emergence of multidrug resistant acinetobacter blood stream infections in febrile neutropenia patients with haematological cancers and bone marrow failure syndromes. J Indian Med Assoc 2012; 110: 439-44.
- Kaur M, Gupta B, Sharma A, Sharma SK. Child with aplastic anemia: Anesthetic management. Saudi J Anaesth 2012;6:298-301.
- Sharma SK, Dwivedi S, Mehrotra G, Ramachandran V.G. Endothelial dysfunction in young 1st degree relatives of patients with coronary artery disease. Indian Heart Journal. 2005; 57: 381.
- Dwivedi S, Dwivedi G, Chaturvedi A, Sharma SK. Coronary artery disease in young: heredofamilial or faulty life style or both. J Indian Acad Clin Med. 2000;1:222�229.
- Dwivedi S, Singh S, Melkani G, Agrawal MP, Sharma SK. Recurrent strokes--an interesting pedigree. J Assoc Physicians India. 2001;49:765-766.
- Dwivedi S, Singh S, Melkani GC, Sharma SK. Hypertension, central obesity and coronary artery disease in three generations of a family. Indian J Cardiology. 2000; 2:37.
Pre arrival consultations
There are the top hospital brands and top Doctors, but who suits your medical condition the best is the big question.Our ongoing research on patient outcomes across top hospitals helps us recommend who would suit your medical condition the best.
Did you know that there are 80 super specialists within the paediatricians or would you go to the same paediatrician for any medical problem related to children, be it heart, brain, lungs, Gastro .. and so on for children.
- At first, we help you reach out to the right super speciality,
- Second, we recommend the Doctor who has the best patient outcome for that particular super speciality.
- Third, we get you his opinion and estimated cost for your treatment
- Fourth, we help you with your medical visa
- Fifth, we send you options for everything else like a guest house, local sim card etc that you would need.
Arrival
Our guest relations officer would receive you at the airport, once you send us your arrival details. He would hold a placard with your name written on it, so that you can identify him easily. He then takes you to the hospital our the guest house, as per plan.
Local hotel / Guest House
The attendant(s) have to stay out of the hospital during the surgery day and till patient is under intensive care (ICU), plus the follow up stage after discharge the patient is required to stay outside the hospital. Thus a comfortable, hygienic and affordable guest house accommodation is important, and we help with finding you one that is near the hospital as well. Given that we have a large number of patients coming every year, we are able to negotiate the best rates for you.
Visa Assistance
Getting a medical visa for India is an easy task. The first step is to take an appointment online for applying medical visa through the website of Indian embassy in your country, download
And fill up the forms, attached your local medical reports and the opinion received from India along with the Visa invitation letter from the Hospital in India. Any assistance you need, besides the medical visa invitation letter is provided.
Concierge
While in hospital, the whole process starting from registration and going through various tests and consultations pre surgery and till discharge after that can be daunting for the patient and the attendant.
Our concierge helps our patients by being with them in the hospital�at every step, �of the treatment process, including routine administrative tasks like registration to being with you during your meeting with the specialist Doctor.
Local SIM Card
Staying in touch locally, as well with family back home in your country is important. A local sim with internet connection is provided the same day on request. Most phones come with a dual sim, so you can keep running your messaging and other apps without having to pay for international roaming on your country' sim card.
Funds assistance
In case you are running short of funds, required for your treatment, we offer some solutions. Please send us an email or talk to us for assistance.
Discharge
Understanding the discharge summary, including what to do once the patient is out of the hospital, medicines to be given, along with settlement of the bill, ensuring the costs are controlled are the help areas we provide the patients with.
Food
While in hospital, the patient gets healthy food in the hospital itself. The food for attendant(s) has to be arranged outside. Our guests choose from a wide range of cuisine available on room delivery, dine in and self cooked in the guest house.